Publications of Jennifer Munkert

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Munkert J, Santiago Franco M, Nolte E, Thaís Silva I, Oliveira Castilho R, Melo Ottoni F, Schneider NFZ, Oliveira MC, Taubert H, Bauer W, Andrade SF, Alves RJ, Simões CMO, Braga FC, Kreis W, de Pádua RM (2017) Production of the Cytotoxic Cardenolide Glucoevatromonoside by Semisynthesis and Biotransformation of Evatromonoside by a Digitalis lanata Cell Culture. Planta Medica 83: 1035-43 (DOI:10.1055/s-0043-109557)

Nolte E, Wach S, Thais Silva I, Lukat S, Ekici A B, Munkert J, Frieder Müller-Uri F, Kreis W, Simões CMO, Vera J, Wullich B, Taubert H, Lai X (2017) A new semisynthetic cardenolide analog 3β-[2-(1-amantadine)-1-on-ethylamine]-digitoxigenin (AMANTADIG) affects G2/M cell cycle arrest and miRNA expression profiles and enhances proapoptotic survivin-2B expression in renal cell carcinoma cell lines. Oncotarget (DOI:10.18632/oncotarget.14644 )

Meitinger N, Munkert J, Pádua RM, Dias de Souza JF, Maid H, Bauer W, Braga FC, Kreis W (2016) The catalytic mechanism of the 3-ketosteroid isomerase of Digitalis lanata involves an intramolelcular proton transfer and the activity is not associated with the 3β-hydroxysteroid dehydrogenase activity. Tetrahedron Letters 57: 1567-1571 (DOI:10.1016/j.tetlet.2016.02.099)

Ernst M, Munkert J, Campa M, Malnoy M, Martens S, Müller-Uri F (2015) Steroid 5β-reductase from leaves of Vitis vinifera: molecular cloning, expression and modelling. Journal of Agriculture and Food Chemistry 63: 10112-10120 (DOI:10.1021/acs.jafc.5b04261)

Petersen J, Lanig H, Munkert J, Bauer P, Müller-Uri F, Kreis W (2015) Progesterone 5β-reductases/iridoid synthases (PRISE): gatekeeper role of highly conserved phenylalanines in substrate preference and trapping is supported by molecular dynamics simulations. Journal of Biomolecular Structure and Dynamics 2015 Oct 12:1-14 (DOI:10.1080/07391102.2015.1088797)

Munkert J, Costa C, Budeanu O, Petersen J, Bertolucci S, Fischer G, Müller-Uri F, Kreis W (2015) Progesterone 5β-reductase genes of the Brassicaceae family as function-associated molecular markers. Plant Biology 17: 1113-1122 (DOI:10.1111/plb.12361)

Munkert J, Pollier J, Miettinen K, van Moerkercke A, Payne R, Mueller-Uri F, Burlat V, O'Connor S, Memelink J, Kreis W, Goosens A (2015) Iridoid Synthase Activity is Common among the Plant Progesterone 5β-Reductase Family. Molecular Plant 8: 136-152 (DOI: 10.1093/mp/ssu100)

Munkert J, Ernst M, Mueller-Uri F, Kreis W (2014) Identification and stress-induced expression of three 3β-hydroxysteroid dehydrogenases from Erysimum crepidifolium Rchb. and their putative role in cardenolide biosynthesis. Phytochemistry 100: 26-33

Munkert J, Bauer P, Burda E, Müller-Uri F, Kreis W (2011) Progesterone 5β-reductase of Erysimum crepidifolium: cDNA cloning, expression in Escherichia coli, and reduction of enones with the recombinant protein. Phytochemistry. 72: 1710-1717

Bauer P, Munkert J, Brydziun M, Burda E, Müller-Uri F, Gröger H, Muller YA, Kreis W (2010) Highly conserved progesterone 5β-reductase (P5βR) genes, from 5β-cardenolide-free and 5β-cardenolide-producing angiosperms. Phytochemistry. 71 (13): 1495-1505

Book chapter

Kreis W, Munkert J, Maia de Pádua R (2017) Biossíntese de metabólitos primários e secundários. In: Farmacognosia do Produto Natural ao Medicamento. Simões CMO, Schenkel EP, Mello JCP, Mentz LA, Petrovick PR. Artmed Editora Ltda. Capitulo 11, 147 - 166 (ISBN 978-85-8271-359-4)